Peptide · Cognitive enhancement
Semax is a synthetic ACTH(4-10) analog studied as a neuroprotective and nootropic peptide.
Semax is a synthetic ACTH(4-10) analog studied as a neuroprotective and nootropic peptide.
Semax is a synthetic heptapeptide derived from a fragment of ACTH (adrenocorticotropic hormone). It modulates BDNF and neurotrophin expression, monoaminergic signaling (dopamine, serotonin, norepinephrine), and has neuroprotective effects in animal models of stroke and traumatic brain injury. Developed in Russia and approved there for stroke recovery and cognitive dysfunction.
Russian clinical research; limited Western trials.
Compounded — not FDA-approved.
Most common form: intranasal spray, 250 mcg–1 mg per dose, 1–3 times daily depending on protocol. Two concentrations exist: 0.1% (lower-dose nootropic use) and 1% (clinical use for stroke and severe cognitive dysfunction). Cycle length is typically 2–4 weeks on, with breaks.
Dosing in research and clinical-use contexts varies. Specific protocols should always be set by a prescribing clinician, not by patient-direct sources.
Generally well-tolerated. Reported side effects: mild stimulation, occasional headache, nasal irritation. Some patients report difficulty sleeping if dosed late in the day.
Semax is commonly combined with selank (anxiolytic) for balanced cognitive + emotional support. Some protocols layer with cholinergic supplements (alpha-GPC, citicoline) for additive memory effects.
Most peptides discussed on this page are compounded products requiring a prescription from a licensed clinician. Reputable telehealth peptide programs include physician-led oversight, accredited compounding pharmacies, and clear regulatory framing. For weight-management GLP-1 programs, see our provider reviews.
Semax is a synthetic ACTH(4-10) analog studied as a neuroprotective and nootropic peptide.
Compounded — not FDA-approved.
Uses include: Cognitive support (research), Stroke recovery (Russian clinical use). This is research and clinical-use context, not a recommendation. Always work with a licensed clinician.
Russian clinical research; limited Western trials.
Reported dosing: Intranasal, 250–600 mcg per dose. Actual dosing should always be determined by your prescribing clinician, not by online sources.
Semax is more stimulating and cognitive-focused; selank is more calming and anxiolytic. Many users combine the two for balanced effects.
No dependence or withdrawal pattern has been documented in available data. Tolerance can develop with continuous use, which is why cycling is recommended.